ABOUT US OUR PRODUCTS & PIPELINE BUSINESS DEVELOPMENT OUR INVESTORS PRESS ROOM CONTACT US
 

ANNOUNCEMENTS

PRESS MATERIALS

PRESENTATIONS

RESEARCH ARTICLES

 

Research Articles

Novel Function of CRTH2 in Preventing Apoptosis of Human Th2 Cells through Activation of the Phosphatidylinositol 3-Kinase Pathway
Xue L et al
J Immunol. 2009 Jun;182(12):7580-7586
 
Interaction between prostaglandin D2 and chemoattractant receptor-homologous molecule expressed on Th2 cells mediates cytokine production by Th2 lymphocytes in response to activated mast cells
Xue L et al
Clin Exp Immunol. 2009 Apr;156(1):126-133
 
A paracrine role for chemoattractant receptor-homologous molecule expressed on T helper type 2 cells (CRTH2) in mediating chemotactic activation of CRTH2+CD4+ Th2 lymphocytes
Vinall SL et al
Immunology 2007 Aug;121(4):577-584
 
Inhibition of PI3K and calcineurin suppresses chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)-dependent responses of Th2 lymphocytes to prostaglandin D2
Xue L et al
Biochem Pharmacol. 2007 Mar;73(6):843-853
 
A dominant role for chemoattractant receptor-homologous molecule expressed on T helper type 2 (Th2) cells (CRTH2) in mediating chemotaxis of CRTH2+CD4+ Th2 lymphocytes in response to mast cell supernatants
Gyles SL et al
Immunology 2006 Nov;119(3):362-368
 
Prostaglandin D2 Causes Preferential Induction of Proinflammatory Th2 Cytokine Production through an Action on Chemoattractant Receptor-Like Molecule Expressed on Th2 Cells
Xue L et al
J Immunol. 2005 Nov;175(10):6531-6536
 
Indole-3-acetic acid antagonists of the PGD2 receptor CRTH2
Armer RE et al
J Med Chem. 2005 Oct;48(20):6174-6177
 
Association of the TSHR gene with Graves’ disease: the first disease specific locus
Dechairo BM et al
Eur J Hum Genet. 2005 Nov;13(11):1223-30

Review Articles

Antagonists of the prostaglandin D2 receptor CRTH2
Pettipher R. and Hansel T T
Drugs News and Perspectives 2008 Jul/Aug;21(6):317-22
 
The roles of the prostaglandin D2 receptors DP1 and CRTH2 in promoting allergic responses
Pettipher R
British Journal of Pharmacology 2008 Mar;153(S1):S191-S199
 
Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic disease
Pettipher R et al
Nat Rev Drug Discov. 2007 Apr;6(4):313-25
 
Identification of G-protein-coupled receptors involved in inflammatory disease by genetic association studies
Pettipher R et al
Current Opinion in Pharmacology 2005 Aug;5(4):412-417
 
The application of genetics to the discovery of better medicines
Pettipher R and Cardon L
Pharmacogenomics 2002 Mar;3(2):257-263.
Oxagen Limited, 91 Milton Park, Abingdon, Oxfordshire OX14 4RY   t : +44(0) 1235 443300  f: +44(0) 1235 443301  e: oxagen@oxagen.co.uk