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Research Articles

A randomized, double-blind, placebo-controlled study of the CRTH2 antagonist OC000459 in moderate persistent asthma
Barnes N, et al
Clin Exp Allergy. 2011 Jul 15. doi: 10.1111/j.1365-2222.2011.03813.x
 
Novel Function of CRTH2 in Preventing Apoptosis of Human Th2 Cells through Activation of the Phosphatidylinositol 3-Kinase Pathway
Xue L et al
J Immunol. 2009 Jun;182(12):7580-7586
 
Interaction between prostaglandin D2 and chemoattractant receptor-homologous molecule expressed on Th2 cells mediates cytokine production by Th2 lymphocytes in response to activated mast cells
Xue L et al
Clin Exp Immunol. 2009 Apr;156(1):126-133
 
A paracrine role for chemoattractant receptor-homologous molecule expressed on T helper type 2 cells (CRTH2) in mediating chemotactic activation of CRTH2+CD4+ Th2 lymphocytes
Vinall SL et al
Immunology 2007 Aug;121(4):577-584
 
Inhibition of PI3K and calcineurin suppresses chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)-dependent responses of Th2 lymphocytes to prostaglandin D2
Xue L et al
Biochem Pharmacol. 2007 Mar;73(6):843-853
 
A dominant role for chemoattractant receptor-homologous molecule expressed on T helper type 2 (Th2) cells (CRTH2) in mediating chemotaxis of CRTH2+CD4+ Th2 lymphocytes in response to mast cell supernatants
Gyles SL et al
Immunology 2006 Nov;119(3):362-368
 
Prostaglandin D2 Causes Preferential Induction of Proinflammatory Th2 Cytokine Production through an Action on Chemoattractant Receptor-Like Molecule Expressed on Th2 Cells
Xue L et al
J Immunol. 2005 Nov;175(10):6531-6536
 
Indole-3-acetic acid antagonists of the PGD2 receptor CRTH2
Armer RE et al
J Med Chem. 2005 Oct;48(20):6174-6177
 
Association of the TSHR gene with Graves’ disease: the first disease specific locus
Dechairo BM et al
Eur J Hum Genet. 2005 Nov;13(11):1223-30

Review Articles

Antagonists of the prostaglandin D2 receptor CRTH2
Pettipher R. and Hansel T T
Drugs News and Perspectives 2008 Jul/Aug;21(6):317-22
 
The roles of the prostaglandin D2 receptors DP1 and CRTH2 in promoting allergic responses
Pettipher R
British Journal of Pharmacology 2008 Mar;153(S1):S191-S199
 
Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic disease
Pettipher R et al
Nat Rev Drug Discov. 2007 Apr;6(4):313-25
 
Identification of G-protein-coupled receptors involved in inflammatory disease by genetic association studies
Pettipher R et al
Current Opinion in Pharmacology 2005 Aug;5(4):412-417
 
The application of genetics to the discovery of better medicines
Pettipher R and Cardon L
Pharmacogenomics 2002 Mar;3(2):257-263.
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