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GPCR PROGRAMME

CRTH2 PROGRAMME

CCRL2 PROGRAMME

 

CRTH2 Antagonist Programme

Oxagen’s Lead Programme – CRTH2 antagonists for Asthma, allergy and inflammatory Disease.

Oxagen has identified a number of potent antagonists of the CRTH2 receptor which are highly selective small molecular weight compounds with a range of physical properties enabling multiple administration routes to treat a range of allergic and inflammatory diseases in man. To date preclinical activity has been demonstrated in a number of models of asthma and allergic and inflammatory diseases.
The lead molecule ODC9101 is in Phase IIa clinical studies and demonstrates safety and suitability for a once a day oral product to treat, in the first instance, asthma. Other molecules in this and other series, all covered by Oxagen’s patent estate are being developed for a range of other therapeutic indications including rhinitis, atopic dermatitis and allergic conjunctivitis.

Click here for further information on Oxagen's CRTH2 programme

CRTH2 review article published in Current Opinion in Pharmacology

Oxagen Limited, 91 Milton Park, Abingdon, Oxfordshire OX14 4RY   t : +44(0) 1235 443300  f: +44(0) 1235 443301  e: oxagen@oxagen.co.uk